Welcome to the Lorenzo Lab

Our lab uses mouse genetics, live cell imaging, and a wide range of molecular biology and biochemical approaches to understand the roles of cytoskeletal proteins in cellular homeostasis and in human disease.

We study ankyrins, spectrins, and their partners to decode their contribution to neuronal development and brain connectivity, and their involvement in neurodevelopmental and neurodegenerative diseases they are associated with. Another major interest of our lab is to elucidate the molecular mechanisms through which cytoskeleton-associated proteins regulate cellular dynamics and bioenergetics in metabolically active tissues, and how their deficits contribute to obesity, diabetes, and metabolic syndrome.